Meta Cell Technology’s Post

Exciting News for Cell Researchers! - Sartorius just introduced the #CellCelector Configuration Tool 👇 Whether you're working on #singlecell isolation, #colonypicking, or any other #cellbased application – its your ultimate companion to select the right components building a custom platform which suits your individual #research needs. Try It Today!

As simple as 1 - 2 - 3! What a great new tool.

⏰ Join us Wednesday (9/18) at 11:00 (EDT) for a webinar showcasing a scalable manufacturing platform for the purification of stem cell-derived exosomes. Register here➡ https://lnkd.in/eh8aF7tS #Exosomes represent an emerging therapeutic modality with the ability to target a broad spectrum of clinical indications. To realize this potential, challenges impacting clinical manufacturing must be addressed, including the purification of exosomes at scale. That's why RoosterBio and Cytiva collaborated to characterize a scalable exosome #bioprocessing platform, designed to deliver high yields and purity at clinically relevant scales. #extracellularvesicles #advancedtherapy #cellandgenetherapy #regenerativemedicine #stemcells #biomanufacturing

Exocobio Exosomes are nano-sized vesicles ranging from 30-200nm that are present in eukaryotic fluids and facilitate a diverse range of cellular functions. They transfer DNA, RNA, and proteins to other cells, thereby altering the function of the targeted cells. Because of their far ranging potential, exosomes can be commercialized as therapeutic agents, diagnostic tools, and cosmeceuticals. Today, a surging number of companies are developing exosome-based products and technologies. Exocobio Exosomes have technology of isolation & purification technology of 0.1~0.5% Purest exosomes from stem cell conditioned media. #Exocobio #Exosomes #ASCE #HRLV #Nanoparticles #PurestExosomes #Rejuvenation #Hairgrowth #Growthfactors #SkinRejuvenation #Leadermedicalsystems #Regenrativemedicine

Cell therapy effectiveness isn't consistent. Patient differences are a big reason for that. But this paper shows how machine learning could fix it. The authors cover the specific challenge of mesenchymal stromal cell (MSC) therapy for osteoarthritis (OA). - Significant variability in therapeutic outcomes - No personalized treatment strategies - Challenges in optimizing MSC dosage to the patient Methods: - Created a database of clinical data from MSC therapy reports (including patient conditions and treatment parameters) - Developed an algorithm to train a prediction model (pulling from the database created) - Finally, they ran in silico trials to identify optimal personalized treatment regimens and ideal patient profiles for the therapy Results: - In silico trials predict significantly higher recovery rates when using an personalized MSC therapy - Developed guidelines for for MSC dosage, concentration, and patient selection based on physical and disease states - Demonstrated superior short-term pain relief efficacy of MSC therapy over platelet-rich plasma (PRP) therapy While this method is still in the early stages, it shows a lot of promise. More importantly, the in silico trial approach has major potential in the clinic beyond osteoarthritis. Kudos to the authors, great work! Any thoughts on this approach? Drop them in the comments. #celltherapy #innovation #machinelearning #biotechnology

“Moderate is better. CAR-Ts with moderate-affinity antigen-binding domains are more effective and have less off-target toxicity.” These findings from Rui Mao et al. published in Frontiers in Immunology intrigued me, a.o. because it seems so old-school to rely on binding affinity to characterise the potency of a cell therapy. Aren’t there more holistic approaches to assess the potency of a cell therapy? And preferably in such a form factor that it can be used during not only research and development but also as part of the routine manufacturing QC release? Looking forward to hearing your thoughts on this! imec.xpand #ATMP #potency #GeneTherapy #HealthTech #celltherapy #CARTcell #biotechnology #innovation #science

Large-scale bioreactor production of extracellular vesicles from mesenchymal stromal cells

Producing stem cells-derived EVs at scale: in their latest work, Christian M. Capitini & Peiman Hematti at University of Wisconsin-Madison and collaborators assessed the viability of producing MSC-derived extracellular vesicles on a large scale using a bioreactor and to evaluate essential quality control parameters such as identity, sterility, and potency in educating monocytes and enhancing survival in a lethal hematopoietic acute radiation syndrome murine model https://lnkd.in/e4mKTqgs Large-scale cultivation of lipopolysaccharide-primed MSCs in a hollow fiber bioreactor demonstrated efficacy in treating H-ARS, showcasing the potential of a scaled-up manufacturing process for generating an appealing off-the-shelf, cell-free therapy. An article also authored by John Kink, Michael Bellio, Matthew Forsberg, Alexandra Lobo, Anna S. Thickens, Bryson M. Lewis, Irene Ong and Aisha Khan #extracellularvesicles #exosomes #bioreactors #gmpcompliance #stemcells #Vesiculab

Organoids in Biomedical Research: Opportunities and Challenges Organoids are three-dimensional, miniature models of organs and tissues that are grown in vitro from stem cells or other progenitor cells with the ability to differentiate into a cell type found in a given organ or tissue. They closely mimic the structure and function of human organs, making them valuable tools for studying human development, disease modeling, drug discovery, and personalized medicine. https://lnkd.in/gJrnAenM #worldprecision #Organoids

CelCulture® CO₂ Incubator with High-Heat Sterilization: Cell culture is one of the vital procedures in a life sciences laboratory. A major concern in this field is the existence of contaminants. Many sources of contamination could be eradicated through the right implementation of standards in laboratory practices and the usage of proper and certified equipment. Esco is proud to announce the launch of Esco CelCulture® CO2 Incubator with High Heat Sterilization (CCL-HHS). This new product adopts a 180°C dry heat sterilization system, proven effective in killing normally resistant fungi, bacterial spores, and vegetative cells that may contaminate the workspace. This sterilization cycle is more convenient as it eliminates the need to remove chamber components during sterilization and completes within twelve hours leaving the chamber cool and dry at the end of the cycle. The CelCulture® CO2 Incubator with High Heat Sterilization has more design configurations suitable to meet the demands of every cell culture laboratory, taking your scientific dreams a step closer to reality. Applications: Neuroscience Stem Cell Research In Vitro Fertilization Tissue Engineering Cancer Research Mammalian Cell Research