Helge Schnerr’s Post

As simple as 1 - 2 - 3! What a great new tool.

Did you know that the therapeutic potential of Exosomes is directly linked to their source? 🧬 𝐖𝐡𝐚𝐭 𝐃𝐨𝐞𝐬 𝐓𝐡𝐢𝐬 𝐌𝐞𝐚𝐧? The cell type and condition producing the exosomes influence their: - Surface components - Internal cargo (proteins, RNA, etc.) 𝐖𝐡𝐲 𝐢𝐭 𝐦𝐚𝐭𝐭𝐞𝐫𝐬?  Exosomes reflect the traits of their parent cells, making them ideal for targeted, personalized treatments. Exosomes from specific cells, like stem cells or platelets, are designed for more precise and effective therapies tailored to each patient. Check out the evidence in our new e-book, 𝐁𝐫𝐢𝐝𝐠𝐢𝐧𝐠 𝐭𝐡𝐞 𝐄𝐱𝐨𝐬𝐨𝐦𝐞 𝐆𝐚𝐩: 𝐓𝐚𝐜𝐤𝐥𝐢𝐧𝐠 𝐂𝐮𝐫𝐫𝐞𝐧𝐭 𝐌𝐚𝐫𝐤𝐞𝐭 𝐂𝐡𝐚𝐥𝐥𝐞𝐧𝐠𝐞𝐬'📚—a comprehensive resource developed by our scientists and physicians, addressing the current challenges in the exosome market and advancing safer, more effective treatments. Meta Cell Technology🧬 — Breaking the limits of PRP and Autologous Exosomes. 📩 info@metacelltech.com 🔗 www.metacelltech.com #AdvancingTogether with #MCTSystem 💙 #ExosomeTherapy #AutologousExosomes #BiologicalSafety #RegenerativeMedicine #MCTkit #MCTechnology

Why do choosy scientists choose the best cell culture media? Our latest blog post explores why the quality of cell culture media is crucial for successful outcomes. From DMEM to specialized media for 3D cultures and stem cells, discover the impact of high-quality media and reagents. Sneak peek:  Quality ingredients for cell growth and division  Tailored media for advanced cell cultures  The role of RUO cytokines in cell therapy  High-efficiency transfection reagents  Ensuring GMP standards in cell culture Read more: https://ow.ly/Cnqy50TMuW0 #cellculture #cellculturemedia #celltherapy #stemcells #transfection #3Dcellcultures

⏰ Join us Wednesday (9/18) at 11:00 (EDT) for a webinar showcasing a scalable manufacturing platform for the purification of stem cell-derived exosomes. Register here➡ https://lnkd.in/eh8aF7tS #Exosomes represent an emerging therapeutic modality with the ability to target a broad spectrum of clinical indications. To realize this potential, challenges impacting clinical manufacturing must be addressed, including the purification of exosomes at scale. That's why RoosterBio and Cytiva collaborated to characterize a scalable exosome #bioprocessing platform, designed to deliver high yields and purity at clinically relevant scales. #extracellularvesicles #advancedtherapy #cellandgenetherapy #regenerativemedicine #stemcells #biomanufacturing

Cell-based therapies to restore the myocardium offer a pragmatic approach that provides hope for the treatment of #heart failure (HF). In this paper, the authors aimed to review the progress to date in the development of cell-based therapies for HF, summarizing early clinical data from double-blind trials of first-generation multipotent cell therapies, before focusing on preclinical data and ongoing clinical trials for next-generation therapies based on human pluripotent stem cells. 📝 Unlocking the Pragmatic Potential of Regenerative Therapies in Heart Failure with Next-Generation Treatments — Kishino and Fukuda. Full text is available 👇 https://lnkd.in/d2ym_BwW #medicine #health #research #science

“Moderate is better. CAR-Ts with moderate-affinity antigen-binding domains are more effective and have less off-target toxicity.” These findings from Rui Mao et al. published in Frontiers in Immunology intrigued me, a.o. because it seems so old-school to rely on binding affinity to characterise the potency of a cell therapy. Aren’t there more holistic approaches to assess the potency of a cell therapy? And preferably in such a form factor that it can be used during not only research and development but also as part of the routine manufacturing QC release? Looking forward to hearing your thoughts on this! imec.xpand #ATMP #potency #GeneTherapy #HealthTech #celltherapy #CARTcell #biotechnology #innovation #science

Stem cells: What are they and why are they important? Watch our video for an easy-to-understand breakdown! We created this video nearly 10 years ago and we are so excited about the progress made since then to advance this promising therapy. For example, clinical trials involving stem cells have skyrocketed from 1,190 (2010-2020) to 6,205 as of today. #StemCells #RegenerativeMedicine #MedicalResearch #ScienceEducation #BioTech #CellTherapy #HealthInnovation #FutureOfMedicine #StemCellResearch #MedicalBreakthroughs

Enhancing cell therapy by selecting cells with high extracellular vesicle secretion: Ke Cheng at Columbia University, Dino Di Carlo at UCLA and collaborators utilized nanovial technology to enrich millions of single cells based on EV secretion, applying this approach to select mesenchymal stem cells with high EV secretion for improved therapeutic treatment https://lnkd.in/gGt2FTNP They found that the selected MSCs exhibited distinct transcriptional profiles linked to EV biogenesis and vascular regeneration, and maintained high levels of EV secretion after sorting and regrowth. An article also authored by Doyeon Felis Koo, Xiao Cheng, Shreya Udani, SEVANA BAGHDASARIAN, Dashuai Zhu, Junlang Li, Brian Hall, Natalie Tsubamoto, Shiqi Hu and Jina Ko #extracellularvesicles #exosomes #MSCs #flowcytometry #bioengineering #Vesiculab

Who can afford to compromise on safety? During the culture of induced pluripotent stem cells (iPSCs), methodologies for the characterization and monitoring of key phenotypic markers, are crucial to ensure the preservation of pluripotency and homogeneity during growth. With cell therapy products, multiple safety issues, call for multiple solutions. This eBook provides a collection of data and methods for culture, optimization, and characterization of iPSCs, using cytometry as an analysis tool. Find out more: https://ow.ly/OkJF50SPPs4 #cellculture #livecellanalysis #highthroughputscreening #HTS #iPSCs #cytometry

A: The project aims to increase the availability of hematopoietic stem cells (HSCs) and progenitor cells (HPCs) through ex vivo culture methods, allowing a single donor to potentially support multiple recipients. Small molecules will be screened to promote HSC self-renewal while preserving their stemness. Additionally, a BioBank of in vitro expanded HSCs will be created for immediate, cryogenically stored access, significantly reducing wait times and improving transplant outcomes for patients. ❓Have questions? Drop them in the comments!❓ #TeamInsightThursday #CellTherapy #StemCells #Innovation #GeneTherapy #CellTherapyOperations #BloodCancers #CellProcessing #Biobank #MobilizedBloodStemCells #Research