[en] A solution of radioactive, 50 to 2,000 MBq, Na¹²³I or Na¹²⁵I or Na¹³¹I is used to act upon a prepared reaction mixture of an aqueous solution of chromatographically pure monoiodobromosulfophthalein of a concentration of 10^-1 to 10^-4 mol/l and pH 2.0 to 9.0, with copper chloride of a concentration of 10^-2 to 10^-5 mol/l. The solution thus obtained is heated to a temperature of 80 to 120 degC and mixed in a ratio of 1:5 to 1:20 with a nonradioactive solution containing sodium dihydrogen phosphate of a concentration of 10^-2 to 10^-6 mol/l and Complexon 3 of a concentration of 10^-3 to 10^-6 mol/l. The procedure is advantageous in mass production of radiopharmaceuticals. (J.B.)

[en] The first nonradioactive solution is prepared from o-iodohippuric acid of a concentration of 10^-1 to 10^-4 mol/l and pH=3.5 to 6.0, and copper(I) chloride or bromide of a concentration of 10^-2 to 10^-7 mol/l. Following filtration, 2 ml of this solution are put in 10 ml test tubes. The second nonradioactive solution is prepared from sodium dihydrogen phosphate of a concentration of 10^-2 to 10^-6 mol/l and Complexon-III of a concentration of 10^-2 to 10^-6 mol/l. After filtration 7 ml of this solution are put in 10 ml test tubes. Both solutions may be prepared in advance and stored under sterile conditions in closed test tubes at temperatures of 0 to 4 degC for a period of 3 to 4 months. The radioactive solution of o-iodohippuric acid is prepared by adding the required amount of a Na¹²³I, Na¹²⁵I or Na¹³¹I solution to the first nonradioactive solution. The thus produced solution may be heated and is then mixed with the second nonradioactive solUtion. In this manner preparations may be produced immediately prior to application in nuclear medicine. (E.S.)

[en] The gaseous mixture of xenon difluoride and radioactive iodine passes through a column with aluminium oxide which is gradually heated to 1000 K. The fluorine thus obtained is trapped in the column. Radioactive iodine and xenon pass freely. Behind the column, ¹²⁵I is trapped in a medium which binds iodine. The advantage of the procedure is that no hydrogen fluoride or hydrofluoric acid develop which have strong corrosive effects. Common quartz apparatus may thus be used for the separation. Another advantage is that radioactive iodine may be trapped in an arbitrary medium which allows to carry out further radioiodination also in non-aqueous media. (E.S.)

[en] The state of trace cadmium in aqueous nitrate solutions has been analysed by dialysis, centrifugation and electromigration. It has been found that Cd²⁺ ions prevail in solutions of pH < 5, whereas colloidal forms are present at higher pH, together with the ionic or molecular products of cadmium hydrolysis. The nature and abundance of the colloids depends on the concentration of cadmium. Mostly pseudocolloids are formed in greater than or equal to 5 x 10^-7 M solutions due to adsorption of Cd(0H)₂ and Cd0H⁺ on foreign colloidal impurities. At 5 x 10^-6 M polymerisation of the hydrolytic products probably takes place with formation of colloidal cadmium hydroxide, or basic salts. Adsorption of traces of cadmium has been studied on glass and plexiglass as a function of pH, age and composition of the solution and concentration of cadmium. Probable mechanisms of adsorption have been proposed. (author)

[en] To a 10^-2-10^-5 M aqueous-alcoholic solution of thyroxine is added a solution of elemental iodine and immediately after, a solution of radioactive sodium iodide. After a few minutes non-reacted iodide is separated and the preparation is diluted to the required volume activity. The reaction has a yield of ca 80% and the specific activity of the resulting sample is around 4 GBq/mg. The preparation shows good stability for more than 2 months. The obtained labelled thyroxine is used in medicine in vitro for examinations of the function of the thyroid. (M.D.)

[en] m-Iodobenzylguanidine can be labelled with radioactive iodine by heating 0.1-1 wt.% aqueous solution of the unlabelled substance with 0.12 wt.% aqueous solution of PdCl₂ for 5 min at 100 degC, adding an aqueous solution of radioactive sodium iodide, and heating the whole at 100 degC for another 30 min. As compared with conventional procedures, lower temperatures are involved, whereby the formation of decomposition products is prevented, and the entire process takes a shorter time. (P.A.)

[en] A solution of 50 to 2,000 MBq Na¹²³I or Na¹²⁵I or Na¹³¹I is used to act upon a prepared reaction mixture of an aqueous solution of chromatographically pure bromosulfophthalein of a concentration of 10^-1 to 10^-4 mol/l and pH 2.0 to 8.0, with hydrogen peroxide of a concentration of 10^-1 to 10^-3 mol/l. The solution thus obtained is heated to a temperature of 80 to 120 degC and mixed in a ratio of 1:5 to 1:20 with a prepared nonradioactive solution containing sodium dihydrogen phosphate of a concentration of 10^-2 to 10^-6 mol/l and Complexon 3 of a concentration of 10^-2 to 10^-6 mol/l. The procedure offers a uniform product within a short time, this of a high yield. It can be applied, e.g., in the production of radiopharmaceuticals. (J.B.)

[en] An aqueous solution containing platinum or palladium ions in an amount corresponding to concentration of the metal between 10 and 10^-6 g/l is first added to the solution or reaction mixture of monoiodohippuric acid in an aqueous solution of a concentration of 10^-1 to 10^-4 mol/l at pH 3.5 to 6.0. An iodide solution containing radioactive iodine with the iodide concentration between 10^-2 and 10^-6 mol/l is then added. The mixture thus formed is left to react for over 1 to 10 minutes. (J.P.)

[en] The filter is designed for the labelling of preparations in cases where the iodination agent is elementary iodine. Its porous material, e.g. filter paper, contains sorbed 1,3,4,6-tetrachloro-3α,6α-diphenylglycoluril derivative. The filter can involve another layer of a porous material with sorbed silver chloride or sodium pyrosulfite; filter paper can constitute a next layer, followed by a membrane filter 0.22 to 0.4 μm in pore size. The inclusion of additional layers free from active substances is feasible. In its compound design the filter enables all the operations involved, i.e. labelling, removal of unreacted iodide, and sterilization, to be combined into one. (P.A.)

[en] A new method was developed and tested in pilot plant operation, of the production of sodium ¹²⁵I-iodide from XeF₂ irradiated with neutrons in a nuclear reactor. ¹²⁵I was separated from the irradiated target by sublimation at a temperature of 923 K and subsequently of 1078 K. Its absorption in 1 to 5 ml of a 10^-2 M NaOH solution results in its transformation to sodium ¹²⁵I-iodide. A minimum activity of 3.7 GBq/ml, minimum radiochemical purity of 99% in form of I^-and minimum radionuclide purity of 99% ¹²⁵I were obtained. For routine production, a laboratory provided with a shielded box and the necessary single-purpose instruments was put into operation. (B.S.)