PUXANO

𝗣𝗨𝗫𝗔𝗡𝗢'𝗦 𝗘𝗣𝗜𝗧𝗢𝗣𝗘 𝗠𝗔𝗣𝗣𝗜𝗡𝗚 𝗪𝗢𝗥𝗞𝗙𝗟𝗢𝗪 Looking to understand how your mAb, Fab, VHH, or de novo scaffold interacts with a protein target? Need a protein design and engineering team that can quickly set up assays to screen hundreds to thousands of scaffolds in parallel without compromising on deep insights such as binding affinities or protein structures? At PUXANO, we offer a dedicated platform for comprehensive experimental validation and optimization of protein scaffolds. Our end-to-end workflow includes: ✅ Protein production ✅ High-throughput scaffold screening ✅ Binding rate and affinity determination studies (BLI) ✅ Protein stability assessments (DSF & SEC) ✅ Structure determination (CryoEM) We've miniaturized and parallelized key steps, enabling us to process up to 396 conditions within 4-8 weeks, including CryoEM-based structure determination. 💡 Ready to accelerate in-depth protein scaffold development and characterization? 📧 Contact us at info@puxano.com or visit 🌐 www.puxano.com to learn more. #Biotechnology #ProteinScaffold #ProteinEngineering #CryoEM #StructureBasedDesign

𝗣𝗥𝗢𝗧𝗘𝗜𝗡 𝗦𝗧𝗥𝗨𝗖𝗧𝗨𝗥𝗘 𝗗𝗘𝗧𝗘𝗥𝗠𝗜𝗡𝗔𝗧𝗜𝗢𝗡 𝗙𝗥𝗢𝗠 𝗡𝗔𝗧𝗜𝗩𝗘 𝗥𝗘𝗦𝗢𝗨𝗥𝗖𝗘𝗦 Do you want to solve structures under native conditions by isolating them from native cells, resulting in extremely low yields? Do you aim to solve a membrane protein structure in vesicles while preserving the native bilayer environment? Are you struggling with a protein target that you cannot produce at yields high enough for standard cryoEM structure determination (x < 0.5 mg/ml)? At PUXANO, we have developed several 𝗽𝗿𝗼𝗽𝗿𝗶𝗲𝘁𝗮𝗿𝘆 𝗰𝗿𝘆𝗼𝗘𝗠 𝗽𝗿𝗼𝘁𝗲𝗶𝗻 𝘀𝗮𝗺𝗽𝗹𝗲 𝗽𝗿𝗲𝗽𝗮𝗿𝗮𝘁𝗶𝗼𝗻 𝘄𝗼𝗿𝗸𝗳𝗹𝗼𝘄𝘀 𝗮𝗻𝗱 𝗴𝗿𝗶𝗱 𝘁𝘆𝗽𝗲𝘀 that enable us to solve structures at concentrations 1000× lower than state-of-the-art cryoEM workflows. These grids, built upon the PUXANO cryoEM grid framework, allow us to solve structures at concentrations as low as 100–0.1 µg/ml. The versatility of our system enables compatibility with most protein tags or immobilization systems. Strategies we have successfully implemented include: ✅ GFP-Labelled membrane proteins ✅ Biotinylated proteins Furthermore, we also have developed 𝗮 𝗴𝗿𝗶𝗱 𝘁𝘆𝗽𝗲 𝘁𝗵𝗮𝘁 𝗰𝗮𝗻 𝗺𝗮𝘅𝗶𝗺𝗶𝘇𝗲 𝘁𝗵𝗲 𝗱𝗶𝘀𝘁𝗿𝗶𝗯𝘂𝘁𝗶𝗼𝗻 𝗮𝗻𝗱 𝗱𝗲𝗻𝘀𝗶𝘁𝘆 𝗼𝗳 𝗹𝗮𝗿𝗴𝗲𝗿 𝘃𝗲𝘀𝗶𝗰𝗹𝗲𝘀 thereby facilitating the structural validation of membrane proteins in vesicles. PUXANO continually invests in the development of groundbreaking technologies to stay ahead of the curve. We specialize in the challenging proteins that others can’t resolve due to technological limitations—not the low-hanging fruits. This commitment enables us to provide superior solutions that drive innovation in protein structure determination. 💡 Pioneering structure-based protein research of challenging protein targets! Contact us at 📧 info@puxano.com or visit 🌐 www.puxano.com to learn more. #Biotechnology #ProteinDesign #NativeProteinStructureDetermination #CryoEM #StructureBasedDesign

𝗣𝗨𝗫𝗔𝗡𝗢'𝗦 𝗦𝗧𝗥𝗨𝗖𝗧𝗨𝗥𝗔𝗟 𝗩𝗔𝗖𝗖𝗜𝗡𝗢𝗟𝗢𝗚𝗬 𝗦𝗘𝗥𝗩𝗜𝗖𝗘𝗦 Are you seeking innovative strategies in antigen design? At PUXANO, we empower you with cutting-edge solutions by combining the latest AI-based protein design tools with structural biology expertise and a platform for comprehensive experimental validation. Our vaccine design platform offers an end-to-end workflow that includes: ✅ human + AI-driven protein design & refinement ✅ Protein production ✅ mAb binding assays (BLI) ✅ Protein stability assessments (DSF & SEC) ✅ Protein structure determination (CryoEM) We don’t just design proteins—we ensure they’re robust, validated, and ready for downstream in vivo testing. 💡 Unlock the future of antigen and vaccine innovation today! Contact us at 📧 info@puxano.com or visit 🌐 www.puxano.com to learn more. #Biotechnology #AntigenDesign #ProteinEngineering #AIinBiotech #VaccineDevelopment #StructureBasedDesign

𝗝𝗼𝗶𝗻 𝗨𝘀 𝗮𝘁 𝘁𝗵𝗲 𝗗𝗦𝗜 𝗘𝘃𝗲𝗻𝘁 𝗼𝗻 𝗡𝗼𝘃𝗲𝗺𝗯𝗲𝗿 𝟮𝟴! We will participate in the DSI event: "From Bytes to Brilliance: A Stakeholder Perspective on Data Science Challenges" at Hasselt University. During this event, we’ll discuss our collaboration with the Data Science Institute (DSI) in the development of the database for our ProCondor platform, which is focused on protein target analysis for structure-based protein design studies. 📅 When? November 28, 2024 📍 Where? Hasselt University 🔗 More details about the event: https://lnkd.in/efpzGU2u

We were recently featured in the Dutch magazine C2W as a innovative startup! You can read it via this link: https://wllw.co/R7tr7U7iE Thanks #MarysaVandeberg for the interview. #startup #innovation #C2W #StructuralVaccinology #ProteinTx #CropProtection

We recently launched our new website and it should now be easier for you to initiate a service package, project, or long-term collaboration with us. Check out www.puxano.com for our design-to-structure and gene-to-structure workflows supported by our proprietary technology platform. Thanks to #StefVandommele and Henry from #Trompet for their contributions. #StructureBasedVaccineDesign #ProetinTX #CropProtection #ProteinDesign #CryoEM

Our CEO, #WouterVanPutte, will be attending the Annual #PSDI Meeting at Synchrotron #SOLEIL, Paris, November 10-12. If you're interested in learning more about #PUXANO's cutting-edge technology and services in structure-based protein design and cryoEM, feel free to connect and reach out to him directly on LinkedIn to arrange a meeting. More information on: https://lnkd.in/exjZi5VH

Register for the LUMI-BE User Day on Nov 7th to discover how companies like PUXANO leverage EuroHPC and EuroCC support for GPU clusters in open-source R&D.

🌟 We’re excited to announce that Anaïs Bekaert has joined our team as a Protein Scientist. 🌟 Anaïs brings extensive experience in protein production and purification, making her a valuable addition to our company. In her new position she will contribute to the expansion of our service offerings in high-throughput protein expression and characterization and cryoEM protein structure determination. Please join us in welcoming Anaïs to the team. We’re sure her contributions will be key to our growth and success. 📈 #NewMember #ProteinSciences #Startup

Applications are still open for two great positions: ML/DL Engineer and Protein Design CryoEM Scientist! If you're interested, be sure to apply. We’ll begin interviews in early November, so submit your applications before then!