Humabiologics®, Inc’s Post

Comparison of tumor‑targeting properties of directly and indirectly radioiodinated designed ankyrin repeat protein (DARPin) G3 variants for molecular imaging of HER2 Article by Anzhelika Vorobyeva et al, using #Mediso nanoScan® PET/MRI and SPECT/CT systems. #molecularimaging #preclinical #imaging #cancerresearch

A comprehensive kit driving transformation of biomedical research.

🧬 Ready to take organoid research to the next level? Dive into the intricate 3D vascular structures captured through advanced microscopy! 🌱✨This video highlights how our #OrganoidReagentKit enables precise analysis and development of complex tissue models. 🚀 With our innovative solutions, explore how 3D cell culture and organoid technology are transforming biomedical research! 🌐🔬 #OrganoidResearch #3DCellCulture #OrganoidReagentKit #VascularOrganoids #DrugDiscovery #BiotechInnovation #NestBiotech #RegenerativeMedicine #PharmaceuticalResearch

Avoid the hidden costs of tissue reprocessing! Skip Brown says, "The workload cost increase from regular processing with standard results to processing results that require reprocessing is $138.53. That is a 681.5% workload increase, a nearly 700% workload increase every time reprocessing of tissues is required." Learn more about how tissue processing protocols have an impact on your workflow, cost and timely delivery of results. https://ow.ly/L9Rj50POrUf #Histology #LabEfficiency #TissueProcessing #HealthcareInsights In Vitro Diagnostic Use Only

Their abstract: Red-shifted bioluminescence is highly desirable for diagnostic and imaging applications. Herein, we report a semisynthetic NanoLuc (sNLuc) based on complementation of a split NLuc (LgBiT) with a synthetic peptide (SmBiT) functionalized with a fluorophore for BRET emission. We observed exceptional BRET ratios with diverse fluorophores, notably in the red (I674/I450 > 14), with a brightness that is sufficient for naked eye detection in blood or through tissues. To exemplify its utility, LgBiT was fused to a miniprotein that binds HER2 (affibody, ZHER2), and the selective detection of HER2+ SK-BR-3 cells over HER2– HeLa cells was demonstrated.

📢 A new Special Issue "Materials and Methods for Retinal Injury and Repair" is now open for submissions! 🥼 This Special Issue is guest edited by Dr. Jesse Sengillo, from Bascom Palmer Eye Institute, University of Miami, USA. 💡 Topics to be covered in this Special Issue include the use of biomaterials for retinal repair, innovative surgical techniques for treating retinal injuries, advancements in drug delivery systems targeting specific retinal layers, and the development of novel imaging modalities for assessing retinal damage and repair. 🔗 Click the link to access more details about the Special Issue: https://lnkd.in/e6yu-qGg. 🕑 Deadline for manuscript submissions is 30 September 2024. 🎉 Welcome to join us as authors and reviewers! 👏 And welcome to follow our LinkedIn account: https://lnkd.in/grPNkBrg. #retinal #injury #repair #biomaterials #surgical #drug_delivery #imaging #stemcell #gene_therapy #regenerative_medicine

Alliance for Regenerative Medicine published this whitepaper providing examples of the scientific advances in tissue engineering as well as insights from developers and regulators on chemistry, manufacturing, and controls considerations for the industry. Thanx for sharing Lindsay Gasch, PharmD, BCPS, BCACP!

Developing and characterising nanofibrous scaffolds with extracellular vesicles loaded with curcumin: in their latest article, Adrienn Nochta-Kazsoki PharmD, PhD, Dr. Zelkó Romána at Semmelweis University incorporated large curcumin-loaded EVs into fast-dissolving poly(vinyl alcohol) nanofibers through electrospinning, using aqueous PVA solutions. Confocal laser scanning microscopy confirmed the presence of curcumin-loaded lEVs within the nanofibers. https://lnkd.in/gCqubadN Release studies showed high drug concentrations in lEV-containing nanofibers, underscoring the potential of EV-loaded nanofibrous systems for enhanced therapeutic applications and improved patient outcomes. An article co-authored by Krisztina Németh, TAMÁS VISNOVITZ, Dorina Lenzinger and Edit Buzás #extracellularvesicles #exosomes #drugloading #bioengineering #Vesiculab

Why #SpheroidOnChip is Revolutionizing #3DCellCulture Traditional methods like hanging drop cultures and microwell plates have been key in advancing 3D cell culture. However, they come with limitations that can impact the quality of research results. These static environments often face rapid depletion of oxygen and nutrients, along with the accumulation of waste products, which can compromise spheroid viability and skew experimental outcomes (Tevlek 2023 et al.). 💡 Enter Spheroid-on-Chip Technology! Microfluidic chips provide a more advanced and dynamic approach to spheroid culture. Here’s how they overcome the drawbacks of traditional methods: / Precise Microenvironment Control: Microfluidic chips allow for fine-tuned regulation of chemical gradients, pressure, and shear stress, crucial for mimicking the natural conditions within tissues / Direct Perfusion: Unlike static cultures, microfluidic systems continuously supply oxygen and nutrients while removing waste products, significantly enhancing spheroid viability and functionality / 💡 Indirect Perfusion: We use the approach of indirect perfusion via a vascular network. This approach creates an oxygen gradient and supplies fresh nutrients, while avoiding shear stress on the spheroids, closely simulating physiological conditions. With these capabilities, spheroid-on-chip technology offers a more reliable and realistic model for in vivo conditions, paving the way for breakthroughs in drug development, cancer research, and tissue engineering. #SpheroidOnChip #Microfluidics #3DCellCulture #BiomedicalResearch #InVivoModeling

We can't wait to see you for SNMMI this weekend in Toronto! You can schedule a meeting with us in advance here : https://lnkd.in/gaBrpUki Stop by booth SB2 in small business pavilion to learn about our new : - Reagents (new iodinated vitamin E based Fenestra HDVC) - In Vivo Imaging Systems (2D and/or 3D, bioluminescence + fluorescence + SWIR) - Accessories (Mvein Restrainer for Tail Vein Injections) - Services (Tail Vein Injection Dosing) - Softwares (Imalytics Preclinical Image Analysis) #invivoimaging #preclinicalimaging #lifesciences #molecularimaging